Neurotoxicity of Amyloid b-Protein: Synaptic and Lennart Mucke and Dennis J. Selkoe Neurofibrillary Degeneration Biochemistry and Cell Biology of Tau Protein in Eva-Maria Mandelkow and Eckhard Mandelkow Proteolytic Degradation of Amyloid b-Protein
نویسندگان
چکیده
Ralph Nixon Yasuo Ihara, Maho Morishima-Kawashima and Epidemiology of Alzheimer Disease Richard Mayeux and Yaakov Stern Network Dysfunction Neurotoxicity of Amyloid b-Protein: Synaptic and Lennart Mucke and Dennis J. Selkoe Neurofibrillary Degeneration Biochemistry and Cell Biology of Tau Protein in Eva-Maria Mandelkow and Eckhard Mandelkow Proteolytic Degradation of Amyloid b-Protein Takaomi Saido and Malcolm A. Leissring
منابع مشابه
Minocycline blocks c-terminal fragments of amyloid precursor protein-induced neurotoxicity by inhibition of cytochrome c release and caspase-12 activation
Minocycline is a second-generation tetracycline that effectively crosses the blood-brain barrier. It has remarkable neuroprotective qualities in models of cerebral ischaemia, traumatic brain injury, Huntington’s and Parkinson’s diseases. However, there is no evidence about neuroprotective effects of minocycline on AD. Alzheimer’s disease (AD) is a neurodegenerative disorder characterized neurop...
متن کاملMinocycline blocks c-terminal fragments of amyloid precursor protein-induced neurotoxicity by inhibition of cytochrome c release and caspase-12 activation
Minocycline is a second-generation tetracycline that effectively crosses the blood-brain barrier. It has remarkable neuroprotective qualities in models of cerebral ischaemia, traumatic brain injury, Huntington’s and Parkinson’s diseases. However, there is no evidence about neuroprotective effects of minocycline on AD. Alzheimer’s disease (AD) is a neurodegenerative disorder characterized neurop...
متن کاملPhenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells.
One of the key pathological features of Alzheimer's disease is the aggregation of tau protein. We are therefore searching for compounds capable of inhibiting this reaction. On the basis of an initial screen of 200000 compounds [Pickhardt, M., Gazova, Z., von Bergen, M., Khlistunova, I., Wang, Y., Hascher, A., Mandelkow, E. M., Biernat, J., and Mandelkow, E. (2005) Anthraquinones inhibit tau agg...
متن کاملRhodanine-based tau aggregation inhibitors in cell models of tauopathy.
The two histopathological hallmarks that characterize Alzheimer s disease (AD) are the extracellular amyloid plaques that are formed by b-amyloid fragments of the amyloid precursor protein (APP), and intracellular neurofibrillary tangles and neuropil threads, which consist of the microtubule-associated protein tau forming paired helical filaments with highly ordered structures, as recently corr...
متن کاملClogging of axons by tau, inhibition of axonal traffic and starvation of synapses.
Loss of synapses and dying back of axons are considered early events in brain degeneration during Alzheimer's disease. This is accompanied by an aberrant behavior of the microtubule-associated protein tau (hyperphosphorylation, aggregation). Since microtubules are the tracks for axonal transport, we are testing the hypothesis that tau plays a role in the malfunctioning of transport. Experiments...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012